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Fluoride inhibits KCNH2. 1 / 1

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"We found that (1) F (-) slightly shifts the voltage dependence of hERG channel activation to more positive voltages, while Br (-) shifts it to more negative voltages; (2) Br (-) shifts to more positive voltages both the inactivation-voltage relationship and the peak position of channel full activation of hERG; (3) F (-) slows hERG activation, while both F (-) and Br (-) make the channel close faster; (4) neither F (-) nor Br (-) have any effect on hERG inactivation kinetics."

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Fluoride inhibits KCNH2. 1 / 1

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