IndraLab

Statements

COPS5 activates NEDD8. 5 / 5
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"NEDD8 cleavage by CSN is catalysed by CSN5, a Zn (2+)-dependent isopeptidase that is inactive in isolation."
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"CSN5 promotes tumor cell proliferation by depleting NEDD8 to accumulate beta-catenin."
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"The Csn5 subunit in S. pombe and D. melanogaster underlies the Nedd8 isopeptidase activity of the CSN XREF_BIBR."
21151958
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"The Jab1 and MPN domain metalloenzyme (JAMM) motif in the Jab1 and Csn5 subunit was found to underlie CSN 's Nedd8 isopeptidase activity."
12183637
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"Knockdown of the CSN subunit 5 (CSN5) and suppression of CSN mediated removal of Nedd8 (deneddylation) reduce FBP levels in human cells [10,11] indicating that a major function of the CSN is the prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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