IndraLab

Statements

COPS5 activates NEDD8. 4 / 4
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reach
"Knockdown of the CSN subunit 5 (CSN5) and suppression of CSN mediated removal of Nedd8 (deneddylation) reduce FBP levels in human cells [10,11] indicating that a major function of the CSN is the prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23328082
reach
"The Csn5 subunit in S. pombe and D. melanogaster underlies the Nedd8 isopeptidase activity of the CSN XREF_BIBR."
21151958
reach
"The Jab1 and MPN domain metalloenzyme (JAMM) motif in the Jab1 and Csn5 subunit was found to underlie CSN 's Nedd8 isopeptidase activity."
12183637
reach
"NEDD8 cleavage by CSN is catalysed by CSN5, a Zn (2+)-dependent isopeptidase that is inactive in isolation."
25043011