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BAP1 activates apoptotic process. 52 / 55
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"For example, BAP1 can enhance progression through the G1-S checkpoint and subsequently induce cell death by a process with similarities to both apoptosis and necrosis [XREF_BIBR]."
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"Therefore, BAP1 might be serve as a potential target for high-risk NB with amplified MYCN.However, Sime et al. found that BAP1 overexpression could also induce apoptosis to retard BE2C cells proliferation by releasing Bax through 14–3–3 protein interaction and reducing the Bcl-2 expression regardless of BAP1 DUB activity [28]."
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"Inhibition of the neuronal BAP1/P53 axis significantly reduced neurological deficits and neuronal apoptosis and improved neurological dysfunction in mice after SAH."
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"Cytoplasm BAP1 has been described located at the endoplasmic reticulum (ER), and promoting apoptosis through regulating Ca releasing10."
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"In addition to apoptosis, BAP1 also modulates the activation of cysteine-dependent cell death, ferroptosis, by downregulating the expression of SLC7A11, the major transporter for extracellular cysteine uptake."
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"BAP1 depletion reduces colon cancer cell proliferation concomitant with increased apoptosis and defective DNA replication."
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"Also, overexpression of BAP1 promoted cell apoptosis, which was reversed by overexpression SLC7A11 (Figure 6B)."
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"As a deubiquitinating enzyme, BAP1 contributes to gene transcription, cell differentiation, DNA damage repair, apoptosis, and cell metabolism in tumor inhibition."
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"In a BAP1-mutated cell line olaparib plus cisplatin increased apoptosis and senescence suggesting potentiation of the effect of olaparib alone, consistent with observations in other tumor types [49] ."
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"BAP1 stabilized IP3R3 and increased mitochondrial Ca 2+ concentrations and apoptosis; BAP1 (C91S) did not (XREF_FIG and XREF_SUPPLEMENTARY)."
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"In our previous study, we found that ATF2/BAP1 axis mediates neuronal apoptosis after SAH via P53 Pathway [15]."
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"Likewise, A549 cells transfected with the BAP1 siRNA showed suppression of cell apoptosis (XREF_SUPPLEMENTARY), whereas overexpression of BAP1 significantly promoted cell apoptosis (XREF_SUPPLEMENTARY)."
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"Depletion of BAP1 expression in cutaneous melanoma cells reduced proliferation and induced apoptosis, inhibiting tumor growth in vivo, but its overexpression in melanocytes suppressed proliferation [21]."
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"Overexpression of BAP1 significantly reduced cell viability (Figure 9A) and promoted cell apoptosis (Figure 9B), while CsA reversed these results."
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"It was recently implicated as the target of the tumor suppressor BAP1 that triggers apoptosis following exposure to genotoxic stress."
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"The siRNA targeting of 14-3-3-zeta, or treating the cells with BV02, an inhibitor of 14-3-3 scaffolding protein docking sites, mimicked the effect of BAP1 mediated apoptosis."
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"We also provided evidence that BAP1 suppressed cell proliferation and promoted cell apoptosis, suggesting that BAP1 tended to function as a tumor suppressor in lung cancer."
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"In conclusion, treatment of human endothelial cells with BaP1 induces apoptosis and anoikis, independently of Bcl-2 family members Bax and Bcl-xL and associated with caspase-8 activation and cFLIP (L) up-regulation."
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"ATF2/BAP1 Axis Mediates Neuronal Apoptosis After Subarachnoid Hemorrhage via P53 Pathway."
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"Previous reports, including ours, have demonstrated that BAP1 could promote apoptosis and ferroptosis to inhibit tumor development."
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"Our data instead showed that BAP1 depletion suppressed replication fork progression with concomitant induction of replication stress and apoptosis, suggesting that BAP1 promotes colon cancer cell proliferation by increasing the rate of DNA replication."
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"Apoptosis induced by BaP1 on endothelial cells was independent of two Bcl-2 family members (anti-apototic Bcl-xL and pro apoptotic Bax), that did not show any changes in their expression during a 24 h-treatment period."
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"However, the reduced amount of BAP1 in the cytoplasm of BAP1 cells impairs apoptosis and allows survival of cells that have acquired oncogenic mutations."
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"In the cytoplasm, BAP1 modulates the stability of the IP3R3 channel, which allows the flux of Ca + from the endoplasmic reticulum into the mitochondria, where Ca + is required for the Krebs cycle and, at higher doses, to execute apoptosis."
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"The treatment of human endothelial cells with BaP1 induces apoptosis in a manner involving a decrease in levels of IκBα, the inhibitor of NFκB [27] ."
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"The authors concluded that in apoptosis induced by BaP1 proteolytic activity was associated with caspase-8 activation and cFLIP L up-regulation.Our initial experimental approach was to determine wheth[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A previous research by He et al. demonstrated that BAP1 inactivation in mice induced apoptosis in the embryonic stem cells, fibroblasts, and pancreatic and liver tissue but not in melanocytes and meso[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the other hand, BAP1 restoration bas been found to retard cell cycle progression and promote apoptosis of neuroblastoma cells by interacting with 14-3-3 protein [ 34 ]."
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"BaP1 Induces Apoptosis in RKO Cell Line."
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"These results indicate that BaP1 induces apoptosis in RKO cells in a dose-dependent manner."
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"Inactivation of BAP1 causes apoptosis in mouse ES cells, fibroblasts, liver and pancreatic tissue but not melanocytes and mesothelial cells [12]."
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"For example, BAP1-induced apoptosis in neuroblastoma cells is mediated via an interaction with the 14-3-3 protein [33]; thus, the loss of the 14-3-3 protein may lead to loss of BAP1 function (at least partially), even when BAP1 mRNA and DNA are normally expressed."
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"BAP1 inactivation causes apoptosis in mouse embryonic stem cells, fibroblasts, liver, and pancreatic tissue, but not in melanocytes and mesothelial cells [33]."
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"In functional assays, BAP1 was found to inhibit the migration and invasion of LAC cells, and promoted their apoptosis and necrosis."
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"We show that BAP1 inactivation causes apoptosis in mouse embryonic stem cells, fibroblasts, liver, and pancreatic tissue but not in melanocytes and mesothelial cells."
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"BAP1 was found to localize to the ER where it regulates Ca2 + release by binding to the type 3 inositol 1,4,5 triphosphate receptor ( IP3R3 ) , promoting apoptosis ( 4 ) ."
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"In addition, we found that BaP1 accumulates on the lysosome of CRC cells and leads to ROS accumulation, lysosomal membrane permeabilization, cytosolic acidification and apoptotic cell death."
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"In functional experiments, BAP1 has been shown to suppress lung cancer tumorigenesis in athymic nude mice, promote the cell cycle and induce both apoptosis and necrosis."
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"Interestingly B. lanceolatus venom results reproduced the in vivo observations of Jiménez et al [45]; in a murine model of cutaneous tissue damage, class I SVMP, BaP1, causes the apoptosis of keratinocytes without affecting the viability of endothelial cells."
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"However, although UBE4B, BAP1 and BCL2L11 contribute to apoptosis specifically in the double treatment context, it is conceivable that additional genes encoded in the TGFβ1 + MEKi-specific apoptosis signature are involved and that their concomitant upregulation would synergistically enhance the apoptotic effect.While targeted therapies have significantly improved the treatment of melanoma patients in recent years, the problem of resistance formation against those therapies (even when applied in combination) remains [81, 82]."
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"Genetic depletion of BAP1 in melanoma cells reduced proliferation and colony forming capability, induced apoptosis and inhibited melanoma tumor growth in vivo."
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"Functionally, BAP1 promotes apoptosis and necrosis, and down-regulates the migration and invasion abilities of LAC cells."
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"BAP1 downregulation by siRNA inhibited apoptosis induced by the combined treatment of ODN and oxaliplatin/etoposide."
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"BAP1 depletion diminished proliferation, and enhanced apoptosis, both in vitro and in vivo, and phenotypically inhibited tumor growth in mice xenografts."
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"For instance, BAP1 overexpression could induce apoptosis to retard BE2C cells proliferation by releasing Bax through 14–3–3 protein interaction and reducing the Bcl-2 expression regardless of BAP1 DUB activity [28]."
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"In the cytoplasm, BAP1 interacts with type 3 inositol-1,4,5-trisphosphate receptor (IP3R3) at the endoplasmic reticulum and promotes Ca2+ signaling and apoptosis in response to stress ."
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"BAP1 contributes to colon cancer cell proliferation by accelerating DNA replication and suppressing replication stress and concomitant apoptosis."
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"BAP1 also promotes apoptosis by direct action at the endoplasmic reticulum, where it stabilizes a factor via deubiquitination to stimulate the physiological release of calcium ions into the cytoplasm and mitochondria ."
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"49 Moreover, BAP1 induces apoptosis by binding to the 14‐3‐3 protein or suppresses apoptosis by stabilizing liver kinase B1 (LKB1)."
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"Loss of BAP1 or its DUB activity down-regulates IP 3 R3 and calcium flux, thereby preventing apoptosis of cells with DNA damages."
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"It is also prudent to note that expression of BAP1 increased the population of cells that stain positive for both AnnexinV and PI, an indication of late apoptosis and/or necrosis."
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"Therefore, we aimed to confirm the role of BAP1 in SAH-induced apoptosis."
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