IndraLab

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BAP1 activates apoptotic process. 26 / 29
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"For example, BAP1 can enhance progression through the G1-S checkpoint and subsequently induce cell death by a process with similarities to both apoptosis and necrosis [XREF_BIBR]."
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"In the cytoplasm, BAP1 interacts with type 3 inositol-1,4,5-trisphosphate receptor (IP3R3) at the endoplasmic reticulum and promotes Ca2+ signaling and apoptosis in response to stress ."
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"Likewise, A549 cells transfected with the BAP1 siRNA showed suppression of cell apoptosis (XREF_SUPPLEMENTARY), whereas overexpression of BAP1 significantly promoted cell apoptosis (XREF_SUPPLEMENTARY)."
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"It is also prudent to note that expression of BAP1 increased the population of cells that stain positive for both AnnexinV and PI, an indication of late apoptosis and/or necrosis."
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"As a deubiquitinating enzyme, BAP1 contributes to gene transcription, cell differentiation, DNA damage repair, apoptosis, and cell metabolism in tumor inhibition."
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"However, the reduced amount of BAP1 in the cytoplasm of BAP1 cells impairs apoptosis and allows survival of cells that have acquired oncogenic mutations."
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"BAP1 downregulation by siRNA inhibited apoptosis induced by the combined treatment of ODN and oxaliplatin/etoposide."
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"In functional experiments, BAP1 has been shown to suppress lung cancer tumorigenesis in athymic nude mice, promote the cell cycle and induce both apoptosis and necrosis."
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"We show that BAP1 inactivation causes apoptosis in mouse embryonic stem cells, fibroblasts, liver, and pancreatic tissue but not in melanocytes and mesothelial cells."
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"It was recently implicated as the target of the tumor suppressor BAP1 that triggers apoptosis following exposure to genotoxic stress."
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"For example, BAP1-induced apoptosis in neuroblastoma cells is mediated via an interaction with the 14-3-3 protein [33]; thus, the loss of the 14-3-3 protein may lead to loss of BAP1 function (at least partially), even when BAP1 mRNA and DNA are normally expressed."
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"BAP1 was found to localize to the ER where it regulates Ca2 + release by binding to the type 3 inositol 1,4,5 triphosphate receptor ( IP3R3 ) , promoting apoptosis ( 4 ) ."
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"In addition to apoptosis, BAP1 also modulates the activation of cysteine-dependent cell death, ferroptosis, by downregulating the expression of SLC7A11, the major transporter for extracellular cysteine uptake."
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"Functionally, BAP1 promotes apoptosis and necrosis, and down-regulates the migration and invasion abilities of LAC cells."
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"We also provided evidence that BAP1 suppressed cell proliferation and promoted cell apoptosis, suggesting that BAP1 tended to function as a tumor suppressor in lung cancer."
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"BAP1 contributes to colon cancer cell proliferation by accelerating DNA replication and suppressing replication stress and concomitant apoptosis."
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"In the cytoplasm, BAP1 modulates the stability of the IP3R3 channel, which allows the flux of Ca + from the endoplasmic reticulum into the mitochondria, where Ca + is required for the Krebs cycle and, at higher doses, to execute apoptosis."
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"Interestingly B. lanceolatus venom results reproduced the in vivo observations of Jiménez et al [45]; in a murine model of cutaneous tissue damage, class I SVMP, BaP1, causes the apoptosis of keratinocytes without affecting the viability of endothelial cells."
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"Genetic depletion of BAP1 in melanoma cells reduced proliferation and colony forming capability, induced apoptosis and inhibited melanoma tumor growth in vivo."
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"Inactivation of BAP1 causes apoptosis in mouse ES cells, fibroblasts, liver and pancreatic tissue but not melanocytes and mesothelial cells [12]."
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"Apoptosis induced by BaP1 on endothelial cells was independent of two Bcl-2 family members (anti-apototic Bcl-xL and pro apoptotic Bax), that did not show any changes in their expression during a 24 h-treatment period."
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"In conclusion, treatment of human endothelial cells with BaP1 induces apoptosis and anoikis, independently of Bcl-2 family members Bax and Bcl-xL and associated with caspase-8 activation and cFLIP (L) up-regulation."
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"The siRNA targeting of 14-3-3-zeta, or treating the cells with BV02, an inhibitor of 14-3-3 scaffolding protein docking sites, mimicked the effect of BAP1 mediated apoptosis."
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"In functional assays, BAP1 was found to inhibit the migration and invasion of LAC cells, and promoted their apoptosis and necrosis."
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"BAP1 depletion diminished proliferation, and enhanced apoptosis, both in vitro and in vivo, and phenotypically inhibited tumor growth in mice xenografts."
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"BAP1 stabilized IP3R3 and increased mitochondrial Ca 2+ concentrations and apoptosis; BAP1 (C91S) did not (XREF_FIG and XREF_SUPPLEMENTARY)."
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