IndraLab

Statements

USP22 leads to the phosphorylation of STAT1. 4 / 4
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"Indeed, this finding could be confirmed by blocking type I/II IFN signaling with a neutralizing antibody against IFNAR2 that did not affect USP22-induced STAT1 phosphorylation (Fig. xref )."
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"Interestingly, despite efficient KO of the individual PRRs in both NHT and USP22 KO HT-29 cells, additional deletion of RIG-I, MDA5, or TLR3 did not decrease USP22-dependent STAT1 phosphorylation or ISG56 expression (Fig. xref )."
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"Interestingly, despite efficient KO of the 245 individual PRRs in both NHT and USP22 KO HT-29 cells, additional deletion of RIG-I, 246 MDA5 or TLR3 did not decrease USP22-dependent STAT1 phosphorylation or ISG56 247 expression (Figure 4B -D)."
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"Loss of USP22 expression in Caco-2 cells triggered phosphorylation of STAT1 and increased expression of STING, compared to wild-type (WT) and NHT CRISPR/Cas9 control Caco-2 cells (Fig. 6A)."
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