IndraLab

Statements

P5091 inhibits CASC3. 3 / 3
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"In MM cells, the concurrent use of the NEK2 inhibitor INH1 and P5091 markedly impedes cell growth and overcomes NEK2-related and inherent BTZ resistance by modulating the NF-κB and PP1α/AKT pathways [175]."
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"Through high-throughput screening, scientists identified another novel USP7 inhibitor, the thiophenyl compound P5091, which induces apoptosis in BTZ-resistant MM cells."
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"The combination treatment with P5091 significantly reversed the BTZ resistance in MM cells with high levels of CRIP1 (Fig. 7b and c)."
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