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ATXN3 deubiquitinates KLF4. 9 / 9
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"For example, studies have shown that ATXN3 can promote breast cancer metastasis by deubiquitinating KLF4."
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"ATXN3, a deubiquitinating cysteine enzyme, deubiquitinates KLF4 in breast cancer [208]."
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"29 Moreover, recent reports have found that ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4."
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"Additionally, ATXN3 was highly expressed in breast cancer and it promotes tumor tissue metastasis by deubiquitinating and stabilizing KLF4 [46]."
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"However, the mechansims of ATXN3 up-regulation in breast cancer, how KLF4 promotes breast cancer, and whether aberrant deubiquitination of KLF4 by ataxin-3 is involved in the pathophysiology of MJD, remain to be explored.Another example of ataxin-3's capacity to regulate gene expression via its DUB function is evident in its interaction with histone deacetylase 3 (HDAC3)."
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"Our data show that ATXN3 interacts with KLF4 to antagonize KLF4 ubiquitination."
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"Subsequent immunoprecipitation assays confirmed that <span class="match term0">ATXN3</span> bound to <span class="match term1">KLF4</span>, mediating the deubiquitination and stabilization of <span class="match term1">KLF4</span> protein levels"
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"We also elucidated that ATXN3 promotes breast cancer metastasis by deubiquitinating and stabilizing KLF4, revealing the role of the KLF4 deubiquitinating process in breast cancer metastasis and sugges[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, in breast cancer, ATXN3 promotes metastasis by deubiquitinating KLF4, a transcription factor frequently overexpressed in various human cancers and closely associated with tumorigenesis and tumor progression (16)."
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