IndraLab

Statements


EGFR increases the amount of CYLD. 3 / 3
| 3

reach
"Follow-up validation revealed that K. pneumoniae exploits an EGF receptor (EGFR)-PI3K-AKT-PAK4-ERK-GSK3beta signaling pathway to induce the expression of the deubiquitinase CYLD to attenuate the cytokine dependent nuclear translocation of NF-kappaB."

reach
"Finally, we found that CYLD expression was triggered by the multikinase inhibitor, sorafenib, by the inhibition of Raf-1, as well as by the blockage of the pro survival kinases, MEK (U0126) and the epidermal growth factor receptor (AG1478)."

reach
"RT-qPCR results showed that EGFR silencing decreased miR-222-5p expression, but enhanced CYLD expression, whereas miR-222-5p inhibitor increased CYLD expression (Figure 5A)."