IndraLab

Statements

APC_C inhibits USP1. 4 / 4
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"It was recently shown that APC and CCdh1 triggers USP1 degradation specifically in G1 after UV irradiation."
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"The APC dependent inactivation of USP1 thus removes the restraint on K63-Ub generation in a cell cycle dependent manner [90]."
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"USP1 degradation directed by the cell cycle regulator APC/C (cdh1), which marks USP1 for destruction in the G1 phase, is upregulated in CAPNS1 depleted cells."
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"60 As previously reported, USP1 could be degraded by APC/C Cdh1 during G1 phase."
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