IndraLab

Statements

USP18 binds SOCS1. 7 / 7
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sparser
"USP18 interacts with SOCS1 and mediates its K48-linked deubiquitination."
41354823
sparser
"Increased expression of USP18 and SOCS1 has also been associated with reduced HCV clearance ( xref – xref )."
29070670
sparser
"To test this hypothesis, the interaction between USP18 and SOCS1 was first assessed."
41354823
sparser
"It is therefore important to investigate whether the USP18-SOCS1 complex activates CCL8 in AT2 cells through additional signaling pathways."
41354823
sparser
"The results demonstrated that USP18 specifically bound to SOCS1 in the HEK293T cell overexpression system, whereas no interaction was observed with SOCS2 or SOCS3 (Fig. 8a)."
41354823
sparser
"As shown in Fig. 8b, the interaction between USP18 and SOCS1 was disrupted in both the USP18 (112–372) and USP18 (150–372) mutants, highlighting the critical role of amino acids 51–112 in USP18 for this interaction."
41354823
sparser
"These findings indicate that the amino acids 51–112 of USP18 are important for its interaction with SOCS1, forming a USP18-SOCS1 complex in the mitochondria."
41354823