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USP17L2 activates cell population proliferation. 9 / 9
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"Similar to our observations, previous shRNA studies have also indicated that Dub3 knockdown reduces proliferation by inhibiting the G1-S phase cell cycle progression and inhibits chemotaxis [14,15,26][MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Functionally, we found that the effect of DUB3 on cyclin A mediates proliferation of NSCLC cells."
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"Consistently, the EdU assay indicated that DUB3 deficiency could inhibit cell proliferation, which could be rescued by restoration of MAGEA3 (Figures S4F and S4G)."
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"McFarlane et al. identify that USP17 is highly expressed in several tumor biopsies , and USP17 depletion significantly impairs G1-S phase transition and blocks cell proliferation ( 56 ) ."
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"The knockdown of USP17 also suppressed cell proliferation and glycolysis ."
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"In vitro, Dub3 knockdown could inhibit the proliferation of ovarian cancer cells and increase cell apoptosis."
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"As shown in Fig. 5A–D, depletion of DUB3 in HCCLM3 and HepG2 cells significantly reduced cell proliferation."
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"DUB3 may also promote the proliferation of NSCLC by inhibiting Cyclin A degradation."
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"DUB3 has been reported to promote cell proliferation in various cancers, including oral squamous cell carcinoma (OSCC),41 non-small cell lung cancer,33 gastric cancer19 and prostate cancer,42 suggesting that DUB3 may serve as an oncogenic driver to promote tumorigenesis."
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