IndraLab

Statements

Lidocaine inhibits HCN4. 5 / 5
1 | 2 2
sparser
"On the other hand, the local anesthetic lidocaine ( xref ) inhibits HCN1, HCN2, and HCN4 subunits, as well as heteromeric HCN1–HCN2 channels acting in a dose-dependent manner over a concentration range relevant for systemic use [ xref ]."
30134541
reach
"While it remains unknown if lidocaine inhibition of HCN2 and HCN4 is as sensitive to current and voltage as HCN1, there are noted differences in the inhibition of HCN1 and HCN4 isoforms by ivabradine, with only the latter being prominently current dependent 31."
28455536
reach
"Lidocaine inhibited HCN1, HCN2, HCN1-HCN2, and HCN4 channel currents at 100 muM in both oocytes and/or HEK 293 cells; it caused a decrease in both tonic and maximal current (~ 30-50% inhibition) and slowed current activation kinetics for all subunits."
21303986
sparser
"While it remains unknown if lidocaine inhibition of HCN2 and HCN4 is as sensitive to current and voltage as HCN1, there are noted differences in the inhibition of HCN1 and HCN4 isoforms by ivabradine, with only the latter being prominently current-dependent xref ."
28455536
ctd
No evidence text available
19498275