IndraLab

Statements

USP18 activates IFNs. 2 / 2
| 2
reach
"Alternatively, USP18 antagonists or strategies promoting USP18 degradation could promote the beneficial effect of therapeutic IFNs used in multiple sclerosis, hairy cell leukemia, and melanoma (Meuwissen et al., 2016)."
32039148
reach
"Therapeutically, USP18 represents an attractive target, with agonists being of use in clinical settings where there is overabundance of type I IFNs and USP18 antagonists acting to prolong the beneficial effects of therapeutic IFNs, as in multiple sclerosis, hairy cell leukemia, and melanoma."
27325888