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TFPI leads to the phosphorylation of USP22. 7 / 7
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"Treatment of mice with the AKT inhibitor completely abolished EPI-induced USP22 phosphorylation in 4T1 tumors (fig."
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"These results indicate that EPI stabilizes USP22 through AKT-mediated USP22 phosphorylation."
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"These results indicate that EPI induces USP22 phosphorylation both in vitro and in tumor tissues in an AKT-dependent manner.We then analyzed the phospho-USP22 (p-USP22) levels by IHC staining using specific antibodies to one of the USP22 phosphorylation sites, T147, that is catalyzed by AKT (Fig. 6, A and B)."
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"These results indicate that EPI induces USP22 phosphorylation both in vitro and in tumor tissues in an AKT-dependent manner."
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"Further treatment with the AKT-specific inhibitor largely diminished EPI-induced USP22 phosphorylation ( xref ), indicating that AKT is a kinase for USP22 phosphorylation in breast cancer cells upon EPI stimulation."
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"Consistent with our conclusion that EPI induces USP22 phosphorylation through AKT activation, we observed a statistically substantial increase in p-USP22 levels in breast cancers from EPI versus EPI groups (Fig. 6, J and K)."
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"Consistent with our conclusion that EPI induces USP22 phosphorylation through AKT activation, we observed a statistically substantial increase in p-USP22 levels in breast cancers from EPI high versus EPI low groups ( xref )."
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