IndraLab

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(+)-artemisinin inhibits RELA. 5 / 5
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"To determine if one or more of these sites plays a role in conferring artemisinin responsiveness to the CDK4 promoter, chromatin immunoprecipitation was used to directly determine whether artemisinin disrupts the endogenous interactions of Sp1, AP-1, p50, and p65 with the CDK4 promoter."
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"Our results provide direct evidence that artemisinin disrupts interactions of the p50 and p65 subunits of NF-kB with a critical cell cycle target gene promoter to mediate an anti-proliferative response in human endometrial cancer cells."
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"Subcelluar fractionation revealed that the exogenous p65 NF-kappaB subunit that is produced from the p65-CMV expression vector accumulated in the nucleus of artemisinin treated and untreated cells to approximately the same extent (XREF_FIG) and therefore overrides the artemisinin disruption of endogenous p65 nuclear accumulation."
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"Artemisinin treatment rescued nephrectomy induced reduction of IkappaBalpha and attenuated nephrectomy induced nuclear accumulation of p65."
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"Therefore, given the observed effects of artemisinin disrupting the binding of NF-kappaB subunits p65 and p50 to the CDK4 promoter, we investigated whether artemisinin disrupts NF-kappaB localization into the cell nuclei."
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