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Statements

IHC increases the amount of BAP1. 17 / 17
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"Loss of BAP1 Expression by IHC Identifies a Morphologically Distinct Subset of Tumors."
22367297
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"These data are consistent with those of XREF_BIBR) for both patient survival based on the BAP1 mutational status (32 vs 133 months for BAP1 mutation positive vs BAP1 mutation negative tumours) or BAP1 protein expression (31 vs 133 months for tumours showing negative BAP1 expression by IHC vs those with positive BAP1 expression) and thus the proposed role of BAP1 in the pathogenesis of UM with an aggressive phenotype."
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"Our observation that a greater number of tumors exhibited loss of BAP1 protein expression by IHC compared with BAP1 deletions or mutations indicates that BAP1 may become functionally inactivated by mechanisms other than deletions or mutations in the coding region; for example, epigenetic changes leading to silencing of the BAP1 gene or other, yet to be identified, alterations that prevent BAP1 expression."
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"2.2 PBRM1 and BAP1 Protein Expression by IHC."
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"However, none of these harbored deletions of p16/CDKN2A in reactive stroma, which could allow for more accurate differentiation of BM from EM with reactive stroma when in combination with BAP1 expression by IHC."
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"In this pilot study, we investigated whether loss of BAP1 expression by IHC is associated with prognosis in uveal melanoma patients."
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"As anticipated, we identified a significant association of p16 loss with poor outcomes that was independent of histologic subtype, and as previously reported, that BAP1 expression by IHC is not an ind[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Other malignancies instead express normal levels of BAP1 : for example BAP1 is expressed and detected by IHC in most pancreatic carcinomas [XREF_BIBR], and in most peritoneal and gynecologic serous adenocarcinomas [XREF_BIBR]."
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"In this pilot study, we inves- tigated whether loss of BAP1 expression by IHC is associated with prognosis in uveal melanoma patients."
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"In the current pilot study, we explored the hypothesis that loss of BAP1 expression by IHC is associated with prognosis in patients with uveal melanoma."
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"Recently, loss of BAP1 (BRCA1-associated protein-1) expression by IHC, homozygous deletion of CDKN2A (p16) by FISH, and expression of methyl-thio-adenosine phosphorylase (MTAP) by IHC were added as markers to distinguish non-neoplastic from neoplastic cells when mesothelial proliferation is confined to the serosal surface."
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"Bap1 protein expression by IHC was reduced across lesions and completely absent in approximately 30% (XREF_FIG)."
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"Assessment of BAP1 protein expression by IHC has been shown to be an excellent surrogate for the functional status of BAP1.4,6 Loss of IHC expression correlates with biallelic inactivation of BAP1."
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"The loss of BAP1 expression by IHC is a reliable tool to assess this molecular alteration."
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"XREF_BIBR, XREF_BIBR Loss of PBRM1 or BAP1 expression by IHC is associated with a worse RCC specific survival in ccRCC supporting a role for distinguishing molecular subtypes of ccRCC."
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"In absence of invasion, loss of BAP1 expression by IHC and/or the presence of a homozygous deletion of CDKN2A (p16) by FISH or by methylthioadenosine phosphorylase (MTAP) IHC allow a differential diagnosis between neoplastic and non-neoplastic cells (16-18)."
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"We previously demonstrated that BAP1 and PBRM1 expression by immunohistochemistry (IHC) are highly correlated with mutation status (P = 3E-58 and 4E-23 respectively 34 and that BAP1 and PBRM1 expression by IHC are independent predictors of both disease-free survival and overall survival in the localized disease setting."
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