IndraLab

Statements

MYC increases the amount of USP22. 4 / 4
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"This is significant, as AR upregulation drives the CRPC phenotype, MYC is a known PCa oncogene, and USP22 regulates MYC transcription."
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"The proto-oncogene c-Myc further enhances this expression by inducing elevated levels of USP22, a deubiquitinase."
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"These results suggest that USP22 positively regulates MYC dependent transcription, which may at least partially explain its oncogenic properties."
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"Importantly, c-MYC has been reported to induce the expression of the deubiquitinase USP22, which in turn reduced ubiquitination and enhanced the stability of SIRT1 in CD34 + Flt3-ITD cells."
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