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"In 2023, Cui et al (76) revealed for the first time that IRTKS can induce the deubiquitination of the histone methyltransferase SET domain bifurcated histone lysine methyltransferase 1 (SETDB1), thereby blocking proteasome-mediated SETDB1 degradation and allowing SETDB1 to accumulate through the recruitment of OUT deubiquitinase 4 (OTUD4)."