IndraLab

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USP11 activates 5-formyluracil. 7 / 7
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"Thus, we hypothesized that USP11 could promote resistance to 5-Fu in colorectal cancer by inducing autophagy."
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"In our study, the resistance to 5-Fu induced by USP11 can be weakened by VCP knockdown or autophagy inhibitors."
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"Taken together these data, we hypothesized that USP11 might mediate resistance to 5-Fu by inducing autophagy in colorectal cancer cells and verified the hypothesis in follow-up experiments."
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"The results showed that USP11 overexpression significantly enhanced the resistance of HCT8 cells to 5-Fu compared with the control group, whereas the opposite effect was observed in USP11 knockdown HCT116 cells (P < 0.05, Student 's t test)."
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"The above experimental results have confirmed that USP11 could not only mediate the resistance to 5-Fu, but also induce autophagy in colorectal cancer cells."
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"The experimental results showed that USP11 overexpression could enhance CRC cells resistance to 5-Fu, and knockdown of USP11 could result in CRC cells being more vulnerable to 5-Fu."
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"USP11 promotes 5-Fu resistance through inducing autophagy dependent on VCP."
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