IndraLab
Statements
Saxagliptin activates KCNH2. 1 / 1
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1
reach
"Taken together, saxagliptin and 5-hydroxy saxagliptin had little effect on hERG and IKr currents and on Purkinje-fiber action potentials at concentrations up to 30microM (< = 9.5 microg/mL), suggesting that it is unlikely that either saxagliptin or 5-hydroxy saxagliptin would cause hERG- and IKr-mediated electrocardiographic effects at maximal plasma concentrations associated with the highest recommended saxagliptin therapeutic dose of 5mg [saxagliptin (0.024 mug/mL) and 5-hydroxy saxagliptin (0.047 mug/mL)] in humans."