IndraLab

Statements

USP8 decreases the amount of MHC-I. 4 / 4
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"It has been suggested that inhibition of USP8 increases PD-L1 protein abundance and activates NF-κB signaling to trigger innate immune responses and MHC-I expression."
36388031
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"In addition, USP8 inhibition also triggers innate immune response and MHC-I expression largely through activating the NF-κB signaling."
35361799
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"USP8 blockade enhances the innate immune response and MHC-I expression via the activation of NF-κB signaling."
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"Moreover, USP8 inhibition triggers innate immune responses by activating TRAF6-NF-κB signaling, interferon type I signaling, and MHC-I expression, potentially mitigating the adverse effects of PD-L1 and shaping TME."
39979972