IndraLab

Statements

USP15 binds SMURF2. 15 / 18
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"USP15 can bind SMURF2 to deubiquitinate the TGF-β type I receptor and thus affect tumor development ( xref )."
36530999
biogrid
No evidence text available
26435193
biogrid
No evidence text available
26435193
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"USP15 can bind SMURF2 to deubiquitinate the TGF-β type I receptor and thus affect tumor development (42)."
36530999
sparser
"USP15 binds to Smurf2 complex and deubiquitinates and stabilizes TRβ1, and that apparently leads to boosting of TGF-β-mediated signaling."
25885904
sparser
"USP15 binds to the SMURF2 complex and prevents ubiquitination of the TGF-β receptor resulting in elevated TGF-β signaling."
34814083
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"Using a functional genetic screen we have previously found that USP15 forms a complex with SMAD7 and SMURF2 and is recruited to the TGF-beta receptor complex, where it deubiquitinates and stabilizes TbetaRI XREF_BIBR."
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"Initially, we tested if mutated SMURF2 could form complexes with both SMAD7 and USP15."
26435193
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"The antagonistic actions between ubiquitin ligases and DUBs are responsible for protein homeostasis as exemplified that USP13-FBXL14 regulated reversible ubiquitination of c-Myc in glioblastoma stem cells [ xref ], and USP15-SMURF2 cooperatively modulated TGF-β receptor in glioblastoma [ xref ]."
35931679
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"As shown in XREF_FIG, mutated SMURF2 bound to both USP15 and SMAD7 to the same degree as wild type SMURF2."
26435193
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"For example, glioblastomas can overexpress USP15, which binds to the SMAD7-SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) complex to deubiquitinate and stabilize the type I TGF-β receptor (TβR-I), enhancing TGF-β signaling ."
38503731
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"Furthermore, recent reports have identified a number of shared substrates of SMURF2 and USP15 including MDM2, SMAD3, and RNF20, suggesting that the association between SMURF2 and USP15 may serve as a common regulatory method to control multiple analogous cellular protein complexes XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
26435193
biogrid
No evidence text available
22344298
sparser
"In glioblastoma, USP15 interacts with the SMURF2 complex to deubiquitinate and stabilize the type I TGF-β receptor, boosting TGF-β signaling ( xref )."
40323348
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"USP15 binds to Smurf2 complex and deubiquitinates and stabilizes TRbeta1, and that apparently leads to boosting of TGF-beta-mediated signaling."
25885904