IndraLab

Statements

UCHL5 activates homologous recombination. 6 / 6
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"UCHL5 promotes HR and extensive DNA-end resection."
25194926
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"Since INO80 chromatin remodeling complex had been implicated in DSB-end resection and DSB repair [97,98], UCHL5 may contribute HR via chromatin re-organization such as histone eviction."
28764946
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"Specifically, UCHL5 promotes DNA-end resection and HR through regulating the stability of the NFRKB protein that is a subunit of chromatin remodeling complex INO80 [XREF_BIBR, XREF_BIBR]."
30831436
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"In addition to identifying many DUBs with DDR roles, this work also lead to establish that one, UCHL5 promotes DSB end resection and HR through regulating the stability of the NFRKB protein that is a subunit of chromatin remodeling complex INO80."
25194926
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"The function of UCHL1 in DSB repair is still unclear, but it has been established that UCHL5 promotes repair by enhancing DNA-end resection, whereas BAP1 promotes HR via an unknown mechanism ."
30559450
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"UCHL5 (Ubiquitin carboxyl-terminal hydrolase isozyme L5) positively regulates DSB end resection and HR repair by deubiquitinating and stabilizing NFRKB protein (nuclear factor related to kappaB bindin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28552167