IndraLab

Statements

USP8 binds MYC. 4 / 4
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"Our results showed that Myc-USP8 interacted with Flag-TRAF6 ( xref A, lane 4)."
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"The ubiquitination of TAB2 and TAK1 was markedly attenuated in the presence of Myc-USP8 or Flag-USP8 in a dose-dependent manner ( xref I, lane 4, 6 ; xref J, lane 4, 6 ), as compared with that in the absence of Myc-USP8 or Flag-USP8 ( xref I, lane 3; xref J, lane 3)."
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"As a result, the interaction of USP8 710−1110 with Sec31A was observed only when we used the lysates of cells overexpressing STAM1 ( Fig. 1 E), demonstrating that STAM1, but not STAM2, enables the int[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The ubiquitination of TRAF6 could be seen in the absence of Myc-USP8 ( xref E, lane 2), whereas the marked deubiquitination of TRAF6 was observed in the presence of Myc-USP8 in a dose-dependent manner ( xref E, lane 3–5), indicating that USP8 induces the deubiquitination of TRAF6, as depicted in xref F. The ubiquitinated TRAF6 is associated with the TAK1-TAB1-TAB2 complex and induces the ubiquitination of TAB2 and TAK1, leading to the activation of NF-κB [ xref , xref , xref ]."
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