IndraLab

Statements

Lipopolysaccharide inhibits RIPK1. 3 / 3
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"The altered IL-1beta release has been associated with increased NLPR3 activity and MLKL dependent necroptosis, based on evidence that inhibitors of NLRP3 or MLKL can reduce IL-1beta secretion in LPS stimulated RIPK1 deficient cell lines (BLaER1 and THP1 cells)."
34163478
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"In the BV2 and N9 microglia cell lines, miR-335 strongly counteracted LPS induced proinflammatory gene expression, and downregulated receptor interacting protein 1 (RIP1) and RIP3, two important players of necroptotic and inflammatory signaling pathways."
34211970
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"The LPS or bacterial induced necroptosis in wild type BMDMs was also inhibited by Necrostatin-1 (Nec-1), indicating a RIPK1 kinase dependency (XREF_SUPPLEMENTARY)."
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