IndraLab

Statements


Modified USP9X leads to the deubiquitination of SMAD4. 3 / 3
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"Loss of USP9X therefore prevents deubiquitination of SMAD4, enhancing tumour progression."

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"Strikingly, overexpression of wild-type FAM, but not of the catalytically inactive FAM mutant, inhibited Smad4 monoubiquitination in vivo."

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"Overexpression of FAM also inhibits monoubiquitination of endogenous Smad4."