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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified USP9X leads to the deubiquitination of SMAD4. 3 / 3

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"Loss of USP9X therefore prevents deubiquitination of SMAD4, enhancing tumour progression."

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"Strikingly, overexpression of wild-type FAM, but not of the catalytically inactive FAM mutant, inhibited Smad4 monoubiquitination in vivo."

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"Overexpression of FAM also inhibits monoubiquitination of endogenous Smad4."

19135894

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

Modified USP9X leads to the deubiquitination of SMAD4. 3 / 3

Our Sources:

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