IndraLab

Statements

TP53 binds OTUB1. 21 / 21
5 | 6 10
reach
"For example, OTUB1 could associate with P53 and stabilize P53 signaling."
36271031
sparser
"OTUB1 interacts with p53 and is required for p53 induction in response to DNA damage and p53-dependent apoptosis as well as cell growth inhibition."
32201366
sparser
"Specifically, OTUB1 can directly bind to TP53, thereby regulating the apoptosis process of cells and promoting the expression of apoptotic genes."
33240928
biogrid
No evidence text available
24403071
sparser
"OTUB1, another cytoplasmic DUB, can directly interact with p53, but predominantly stabilises p53 indirectly in the cytoplasm, through a non-catalytic mechanism."
28900014
sparser
"Biochemical interrogation into the OTUB1-P53 interaction revealed that OTUB1 binds to the DNA binding domain of P53 and P53 interacts with the N- and C-termini of OTUB1."
30400005
biogrid
No evidence text available
27561390
sparser
"For example, OTUB1 could associate with P53 and stabilize P53 signaling."
36271031
sparser
"Mechanistically, ASPP1 promoted the ubiquitinated degradation of p53 by inhibiting the binding of deubiquitinating enzyme OTUB1 to p53."
39341821
sparser
"In this study, we found that an abundance of ASPP1 restricted the interaction between p53 and OTUB1, ultimately resulting in the ubiquitination and degradation of p53."
39341821
biogrid
No evidence text available
22124327
biogrid
No evidence text available
22124327
biogrid
No evidence text available
22124327
reach
"These findings indicate that ASPP1 effectively restricts the interaction between OTUB1 and p53 thus mediating its ubiquitination and degradation."
39341821
sparser
"Further study revealed that OTUB1 interacts with P53 and decreases its ubiquitination ( xref )."
38264570
sparser
"The candidate gene is predicted to encode a deubiquitinating enzyme with homology to human OTUB1 ( xref ), a protein associated with the regulation of p53 stability and DNA damage repair xref , xref , xref , xref ."
28776570
reach
"OTUB1, another cytoplasmic DUB, can directly interact with p53, but predominantly stabilises p53 indirectly in the cytoplasm, through a non catalytic mechanism."
28900014
reach
"Mechanistically, ASPP1 promoted the ubiquitinated degradation of p53 by inhibiting the binding of deubiquitinating enzyme OTUB1 to p53."
39341821
reach
"In this study, we found that an abundance of ASPP1 restricted the interaction between p53 and OTUB1, ultimately resulting in the ubiquitination and degradation of p53.Following myocardial infarction, cardiac fibroblasts undergo a phenotypic switch from a quiescent to an activated state."
39341821
reach
"Studies have found that OTUB1 can directly bind and regulate the stability of p53 [141] , while OTUB5 can promote p53 activity by forming a complex with programmed cell death 5 (PDCD5) [142] ."
33421376
sparser
"In detail, OTUB1 could directly bind P53 and deubiquitinates it, which may further improve the stability of P53 mediated by OTUB1, and thus influencing the response to DNA damage and the damaged-regulated autophagy induced by P53."
33240928