IndraLab

Statements


Fisetin inhibits RELA. 4 / 6
2 | 4

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"Further researches proved that fisetin inhibited the excitation of p65 through suppressing IκBα phosphorylation and p65-DNA binding activity and decreased the phosphorylation of Akt and the p38 in the colonal samples of DSS-disposed murines."

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"Furthermore, fisetin disrupts the NF-κB signal transduction pathway targets (p65, IκBα, and cyclinD1) activated by EBV-LMP1, as evidenced by in vitro studies on EBV-infected NPC cells [94]."

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"Furthermore, fisetin treatment also inhibited UVB induced activation and nuclear translocation of NFkappaBp65 as compared to the skin of UVB exposed mice not treated with fisetin (XREF_FIG)."

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"In addition, fisetin reverses the onset of neurodegenerative diseases by countering the NF-κB p65 over expression that induces apoptosis in neurons and Schwann cells."