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Amodiaquine leads to the phosphorylation of AMPK. 7 / 7
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"Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy."
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"Here, we showed that chloroquine and amodiaquine induce mitochondrial biogenesis and balance fusion and fission protein expression in RPTCs under high-glucose conditions and in diabetic kidneys, presumably by enhancing AMPK and PGC1alpha phosphorylation and activity."
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"First, we investigated whether chloroquine or amodiaquine effectively augments AMPK phosphorylation in hRPTCs cultured under high-glucose conditions."
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"At this time, we observed that chloroquine and amodiaquine enhanced AMPK phosphorylation, which led to increased PGC1α activity RPTCs under high-glucose conditions (Figs  xref – xref )."
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"At this time, we observed that chloroquine and amodiaquine enhanced AMPK phosphorylation, which led to increased PGC1alpha activity RPTCs under high-glucose conditions (Figs XREF_FIG - XREF_FIG)."
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"Our findings suggest that chloroquine and amodiaquine successfully enhance AMPK phosphorylation under high-glucose conditions, resulting in increased PGC1alpha phosphorylation."
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"Our findings suggest that chloroquine and amodiaquine successfully enhance AMPK phosphorylation under high-glucose conditions, resulting in increased PGC1α phosphorylation."
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