IndraLab

Statements

USP28 is phosphorylated on S67. 11 / 11
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"Emerging literature suggests that the phosphorylation of USP28 at serine 67 and serine 714 by various kinases enhances its enzymatic activity xref ."
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"In response to IR, USP28 becomes phosphorylated on Ser 67 and Ser 714 in an ATM-dependent manner [ xref ]."
21480003
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"Furthermore, we discovered that SDF-1α influences the turnover of GLI1 protein in GBM cells by modulating GLI1-associated polyubiquitin chains through the phosphorylation of the deubiquitinase USP28 at serine 67."
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"This regulation occurs through the phosphorylation of USP28 at serine 67, enhancing its deubiquitinating enzymatic activity and preventing the ubiquitin-proteasome degradation of GLI1."
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"As previously indicated, it has been proved that phosphorylation of USP28 on serine 67 and serine 714 increases its enzymatic activity upon DNA damage [ xref ]."
| PMC
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"Upon DNA damage, the phosphorylation of USP28 on serine 67 and serine 714 by the kinase ATM increases its enzymatic activity [ xref ]."
| PMC
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"Our results show that, under these conditions, ATM/ATR-mediated phosphorylation of USP28 at S67 and S714 [ xref , xref ] protects it from DYRK2-mediated degradation, allowing USP28 to stabilize DYRK2 and promote p53 phosphorylation at S46, crucial for apoptosis [ xref ]."
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No evidence text available
17525332
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"Considering the phosphorylation of USP28 on serine 67 and serine 714 regulates its enzymatic activity, it could be also possible to develop drugs targeting the phospho-sites."
| PMC
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"The USP25 activity may not be affected upon exposure to an inhibitor blocking the phosphorylation of USP28 on serine 67 and serine It could be another therapeutic option to target the binding between ATM and USP28 and reduce the phosphorylation of USP28, thus decreasing its enzymatic activity in cancer cells with increased DNA damage levels."
| PMC
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"Notably, an increase in USP28 phosphorylation at serine 67 was observed following SDF-1α stimulation, an effect that was diminished by the PI3K/AKT inhibitor GSK690693 (Figure xref I)."
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