IndraLab

Statements

USP28 is phosphorylated on S67. 5 / 6
1 | 5
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"Upon DNA damage, the phosphorylation of USP28 on serine 67 and serine 714 by the kinase ATM increases its enzymatic activity [ xref ]."
| PMC
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"Considering the phosphorylation of USP28 on serine 67 and serine 714 regulates its enzymatic activity, it could be also possible to develop drugs targeting the phospho-sites."
| PMC
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"The USP25 activity may not be affected upon exposure to an inhibitor blocking the phosphorylation of USP28 on serine 67 and serine It could be another therapeutic option to target the binding between ATM and USP28 and reduce the phosphorylation of USP28, thus decreasing its enzymatic activity in cancer cells with increased DNA damage levels."
| PMC
sparser
"In response to IR, USP28 becomes phosphorylated on Ser 67 and Ser 714 in an ATM-dependent manner [ xref ]."
21480003
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"As previously indicated, it has been proved that phosphorylation of USP28 on serine 67 and serine 714 increases its enzymatic activity upon DNA damage [ xref ]."
| PMC