IndraLab

Statements

Phorbol 13-acetate 12-myristate inhibits NFKBIA. 10 / 10
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"Curcumin substantially reduced the fluoride- and TPA induced IkappaBalpha degradation (XREF_FIG) and abolished the p65 phosphorylation, as assessed in cell lysates (XREF_FIG) and p65 translocation to the nuclei (XREF_FIG) after exposure to both agents."
25540590
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"Activation of NF-kappaB is usually associated with the induction of IkappaB phosphorylation; as expected, TPA enhanced the activation of serine 536 phosphorylated NF-kappaB p65 and serine32 phosphorylated I-kappaBalpha and caused the degradation of IkappaBalpha in ECV304 cells (XREF_FIG)."
27654969
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"In addition, bicyclol attenuated TPA induced IkappaB-alpha degradation."
15994005
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"Capsaicin pretreatment significantly suppressed TPA induced degradation of IkappaB-alpha, thereby attenuating nuclear translocation of p65."
11179825
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"However, some carcinogens, e.g., DMBA and 12-O-tetra-decanoylphorbol-13-acetate (TPA), degrade IkappaBalpha by its phosphorylation."
19823771
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"In XREF_FIG, the time courses for fluoride- and TPA induced IkappaBalpha degradation are presented."
25540590
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"TNF-alpha- or TPA induced IkappaBalpha kinase (IKK) activation was also blocked by these inhibitors, which slightly reversed TNF-alpha-induced but completely reversed TPA induced IkappaBalpha degradation."
12645577
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"As expected, TPA increased IKBalpha degradation (Additional file XREF_SUPPLEMENTARY : Figure S1B) and induced binding of p65 to kappaB-RE of MnSOD gene."
24047462
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"Although protocatechuic acid decreased p65-DNA binding, it did not affect TPA stimulated degradation of IkappaBalpha."
20026373
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"The results showed that galangin blocked TPA induced IkappaBalpha degradation by inhibiting the phosphorylation of IkappaBalpha."
25698902