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EIF3F inhibits translation. 37 / 37
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"The same group found that eIF3f overexpression in cancer cells negatively regulates cell growth by affecting the translation efficiency and the activation of apoptosis."
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"Mechanistically, the authors found that eIF3f inhibits both cap dependent and cap independent translation and that eIF3f promotes rRNA degradation through direct interaction with heterogeneous nuclear ribonucleoprotein K."
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"S-glycoprotein of SARS-CoV interacts with the eIF-3f , a subunit of the eukaryotic initiation factor 3 , which results in inhibition of protein synthesis [ 37 ] ."
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"17 Recent studies have shown that eIF3f might not be necessary for global translation initiation, but rather inhibits translation."
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"Shi et al reported that ectopic expression of eIF3f could inhibit nanos1 translation in vitro and in vivo [ 29 ]."
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"Quantification of luciferase mRNA by qRT-PCR demonstrated that translation of luciferase gene was not influenced by overexpression of Mss4 (XREF_FIG), indicating that Mss4 is indeed able to abolish the eIF3f mediated inhibition of translation."
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"Increase in MAFBX (Atrogin-1) promotes muscle atrophy by enhancing the degradation of MyoD (a key muscle transcription factor) and eIF3f (an essential activator of protein synthesis) thereby facilitating decreased protein synthesis in muscle leading to muscle atrophy (Bonaldo and Sandri, 2013; Sanchez et al., 2013)."
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"Overexpression of eIF3f inhibits translation and induces apoptosis in melanoma cells."
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"Our data suggested that eIF3f may inhibit translation by increasing the binding to the eIF3 complex during apoptosis."
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"10 eIF3f belongs to the Mov34 protein family containing the MPN motif 11 and acts as a negative regulator of translation inhibiting both cap dependent and cap independent translation."
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"A subunit of the eukaryotic initiation factor 3, eIF3f, has also been discovered to modulate host translation inhibitory effects through physical interaction with coronavirus spike protein [XREF_BIBR]."
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"By utilizing a bicistronic luciferase report system, it was shown that eIF3f normally inhibits both cap dependent and cap independent (i.e., IRES) mechanisms of translation initiation."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR Advances in the understanding of the molecular mechanism behind cellular carcinogenesis have shown that ectopic expression of eIF3f by transient gene transfection inhibits translation, cellular growth and proliferation and induces apoptosis."
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"Ectopic expression of eIF3f inhibits translation and overall cellular protein synthesis."
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"We can demonstrate that the enforced expression of eIF3f inhibits translation, cell growth, cell proliferation and induces apoptosis in melanoma cells [XREF_BIBR]."
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"Mechanistically, we found that eIF3f inhibited both cap dependent and cap independent translation."
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"Mechanistically, we found that eIF3f inhibited both cap-dependent and cap-independent translation."
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"We also showed that restored eIF3f expression in tumor cells causes ribosomal RNA (rRNA) degradation, inhibits translation and cell proliferation, and induces apoptosis XREF_BIBR."
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"In our current study, we tested the hypothesis that eIF3f coordinates with hnRNP K to regulate rRNA degradation and that decreased eIF3f expression contributes to tumorigenesis by deregulating translation and apoptosis."
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"EIF3f inhibits both cap-dependent and IRES-dependent translation."
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"Whether eIF3f inhibits cap-dependent or cap-independent translation is not known."
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"We also showed that silencing of eIF3f promotes both cap dependent and cap-independent and internal ribosome entry site (IRES)-dependent translation and cytokinesis defects."
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"Taken together, these results suggest that the under-expression of eIF3f protein induces a reduction of fibres size in skeletal muscles.Heterozygous eIF3f mice have a reduced rateof protein synthesisBecause the maintenance of skeletal muscle mass depends on changes in protein synthesis, we evaluated the rate of protein synthesis in our animal models with the SUnSET (Surface sensing of translation) technique."
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"We have shown that eIF3f inhibits translation and induces apoptosis in tumor cells [ xref ]."
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"EIF3f inhibits both cap dependent and IRES dependent translation."
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"In our study, silencing of eIF3f increased both cap dependent and IRES dependent translation (up to 2.5-fold increase), indicating a suppressive role of eIF3f on both translation initiation mechanisms (XREF_FIG)."
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"After anti-Fas or staurosporine treatments in human melanoma cells, the caspase processed C-terminal fragment CDK11p46 strongly interacts with eIF3f via its Mov34 domain [XREF_BIBR] and, due to its kinase activity, phosphorylates eIF3f inducing the inhibition of translation."
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"Ectopic overexpression of each eIF3 subunit (with the exception of eIF3m) in NIH 3T3 cells revealed that subunits eIF3a, eIF3b, eIF3c, eIF3h, and eIF3i stimulated global protein synthesis, accelerated[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown previously by our group, eIF3f can inhibit translation ( xref ) [ xref ]."
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"It is demonstrated that the enforced expression of eIF3f inhibits translation, cell growth, cell proliferation and induces apoptosis in melanoma and pancreatic cancer cells, while knockdown of eIF3f i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"XREF_BIBR Overexpression of eIF3f inhibits cell proliferation, induces apoptosis, and inhibits translation and protein expression."
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"One of the mechanisms of translation inhibition by eIF3f may be eIF3f induced degradation of rRNA XREF_BIBR."
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"Our data support a model (XREF_FIG) in which eIF3f sequesters hnRNP K to inhibit it 's binding to rRNA, which leads to increased rRNA degradation and attenuated translation."
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"We have shown that eIF3f inhibits translation and induces apoptosis in tumor cells [XREF_BIBR]."
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"Our data from HCT116 cells do not support previous conclusions that eIF3f is an inhibitor of global translation (Shi et al, 2006); only 17 mRNAs were increased in the polysomal fraction upon depletion of eIF3f (Fig EV3D)."
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"Additionally, eIF3f interacts with coronavirus spike protein to inhibit host cell translation (Xiao etal., 2008)."
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"Moreover, increased eIF3f inhibits translation and cell growth and induces apoptosis in melanoma and pancreatic cancer cells [XREF_BIBR]."
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