IndraLab

Statements

CLEC16A binds USP8. 6 / 6
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"To evaluate other regulators of CLEC16A turnover, we initially considered the two CLEC16A binding partners USP8 and RNF41."
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"CLEC16A forms a complex together with Nrdp1 and USP8, which promotes mitophagic processes and controls the mitochondrial quality (Pearson et al. 2018)."
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"Recently, USP8, Nrdp1 as an E3 ligase, and Clec16a form a complex that has been proposed to maintain mitochondrial quality in β-cell mitophagy ( Pearson et al., 2018 )."
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"CLEC16A forms a complex with NRDP1 and USP8, and disruption of this complex by metabolic stress reduces mitophagy and β‐cell function 56 , 57 (Figure 1⑤)."
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"Interestingly, Clec16a interacts with endogenous USP8, and this interaction is maintained in the presence or absence of Nrdp1 ubiquitin ligase activity ( xref )."
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"However, Clec16a-USP8 binding as well as USP8 levels are reduced after overexpression of the Nrdp1 K-R mutant ( xref )."
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