IndraLab

Statements

USP15 binds NRF1. 4 / 4
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"In addition, USP15 physically interacts with Nrf1 and also markedly stabilizes the CNC-bZIP protein by removing its ubiquitin moieties, so that this transcription factor is activated to promote expres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Nevertheless, the coexpression of 3 × Flag-Nrf1 caused the nuclear translocation of V5-USP15, implying a physical interaction between USP15 and Nrf1 in cells (top panels)."
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"In contrast, USP15 physically interacts with Nrf1 and also stabilizes Nrf1 by removing its ubiquitin moieties, such that this transcription factor is activated to promote the expression of Nrf1-target proteasomal genes [ xref ]."
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"Consistently, 3 × Flag-Nrf1 was coprecipitated with V5-USP15, indicating that USP15 physically interacts with Nrf1 in cells."
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