IndraLab

Statements


MAP2K1 phosphorylated on S218 is kinase-active. 3 / 3
3 |

"Activation of MEK1 requires the phosphorylation of serine residues 218 and 222."

"Raf-1 activity, measured by the abundance of phosphorylated S217/221 MEK1 2, a direct target of Raf-1 (30) , was consistently elevated in Cdc37 overexpressing cells, whereas total MEK1 2 levels were unchanged."

"Activation of MEK1 and MEK2 involves phosphorylation upon conserved serine residues (Ser-218 and Ser-222 on MEK1, Ser-222 and Ser-226 on MEK2"