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KCNH2 activates cell population proliferation. 64 / 66
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"Blockade of the hERG potassium channel proteins by specific agents can inhibit the proliferation and metastasis of tumor cells and the corresponding [XREF_BIBR, XREF_BIBR], increasing the sensitivity of tumor cells to chemotherapeutic drugs."
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"Yet, a significant number of Tn positive cells were detected in these livers, indicating that the expression of ER-G1, in the absence of NRas, is not toxic but does not induce cell growth or prolifera[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Inhibition of HERG1 K + channel protein expression decreases cell proliferation of human small cell lung cancer cells."
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"HERG potassium channels enhance tumor invasiveness and breast cancer proliferation."
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"In contrast, siRNA induced inhibition of HERG1 protein expression decreased cell proliferation by about 50%."
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"Selective hERG channel blockade by E-4031 reduced proliferation in cancerous cell lines."
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"Arcangeli and co-workers found that hERG channels promoted proliferation in neuroblastoma cells via controlling membrane resting-potential (26)."
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"Considering that inhibition of HERG channels reduces proliferation and impairs invasiveness in several cancer cell types, hERG channels expressed in HEK cells can be target receptor for compounds with[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"HERG1 is over-expressed in various cancer cells and found to promote cell proliferation [XREF_BIBR - XREF_BIBR]."
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"HERG blockers inhibit the proliferation at S and G2/M phase while Eag blocker impramine increases early apoptosis in ovarian cancer cells with no effect on cell cycle."
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"The knockdown of hERG reversed proliferation in a time dependent manner, as the rate of viable cells gradually downgraded to 58.3% +/- 6.4% 72 hours after the administration of nano-siRNA complexes (XREF_FIG)."
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"To test if ER-G1 promotes proliferation in vitro, we generated a series of stable cell lines expressing GFP, Golgi-G1, or ER-G1 in HCC derived HepG2 cells."
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"This suggests that ER-G1 stimulates cancer cell proliferation by enabling tumor expansion rather than directly stimulating cell growth and division.Based on tumor morphology, we hypothesized that ER-G[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The results demonstrated that knockdown of hERG1 in SKOV3 cells significantly reduced the cell proliferation activity compared with the control cells."
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"Pharmacological inhibition of HERG channels reduces proliferation and impairs invasiveness in a variety of cancer cell types."
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"Pastori et al reported that lncRNA HOX transcript antisense RNA (HOTAIR) is an essential driver of GBM cell proliferation; overexpression of HOTAIR in conjunction with I‐BET151 treatment abrogates the antiproliferative activity of the BET bromodomain inhibitor.27 Shi et al found that lncRNA HERG promoted cell proliferation, migration, and invasion by acting as a ceRNA of miR‐940 in GBM.28 AC016405.3, also named RP11‐44N11.2, is a novel lncRNA located at chromosome 8, from 122 779 971 to 122 780 830."
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"Indeed, the knockdown of HERG1 inhibits cell proliferation, while its pharmacological inhibition by E4031 fails to affect cell proliferation."
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"Thus, B-RAF-sensitive hERG K + channel up-regulation possibly contributes to cell proliferation and apoptosis of tumor cells."
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"The selective HERG channel blocker, E-4031, reduced proliferation of CEM, U937, and K562 cells, and this appears to be the first direct evidence of a functional role for the HERG current in cancer cells."
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"In the human neuroblastoma cell line SH-SY5Y [XREF_BIBR] and melanoma cells [XREF_BIBR], not only pharmacological ERG channel blockage but also inhibition of HERG channel protein expression effectively reduces cell proliferation."
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"The proliferation of SK-OV-3 cells is significantly inhibited by both Eag and HERG blockers."
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"Based on the literature validation [61], the hERG potassium channel, which enhances tumor aggressiveness and breast cancer proliferation, is transcriptionally regulated by hsa-miR-362-3p and thus associated with breast cancer growth."
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"E-4031 induced the inhibition of HERG expression and decreased cell proliferation of human small-cell lung cancer cells [15] ."
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"HERG1 Is Functionally Expressed in Insulinoma (INS1E) Cells and hERG1 Blockers Impair cell Proliferation In Vitro."
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"In CRC cell lines, HERG1 presents high expression, and knockdown of HERG1 reduces the proliferation and tumorigenic ability of CRC cells (24)."
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"Our findings suggest that altered ERG1 expression may contribute to disease related smooth muscle proliferation and implicates these ion channels as potential targets as inhibitors of tumor driven neovascularization."
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"Interestingly, in primary cultures from leukaemia blasts, and in many cell lines, hERG1 inhibition tends to block cell proliferation (reviewed in Arcangeli, 2005; Arcangeli and Becchetti, 2005)."
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"Moreover, E-4031, a specific HERG channel blocker, reduced proliferation of uterine cancer cells."
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"One study indicates that inhibition and silencing of the hERG1 protein prevent the proliferation and invasiveness of gastric cancer cells [66]."
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"We consequently chose to use this concentration in all subsequent experiments.In previous studies, we used the patch-clamp technique to test the relationship between SDF-1a and hERG1 Kz channels.10 In this context, we investigated whether the inhibition of hERG1 Kz channels activity would suppress leukemic cell proliferation induced by SDF-1a."
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"For instance, inhibitors of Kv10.1 and hERG channels have been shown to reduce proliferation and induce apoptosis in BC cells (Peretti et al., 2019)."
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"Activation of hERG1 after 48 h of PD 118057 treatment (5 muM and 10 muM) increased proliferation of osteosarcoma cells."
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"In addition, the CCK-8 assay, apoptosis and cell cycle analysis were performed and showed that blockage of HERG K + channels decreased the proliferation of MDS cells but rarely had effects on cell apoptosis and cell cycle distribution."
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"Esophageal squamous cell carcinoma (ESCC) is a highly aggressive and lethal malignancy worldwide that KCNH2 contributes to the poor prognosis of ESCC by promoting ESCC cell proliferation, migration, and invasion via TXNDC5 through PI3K and AKT phosphorylation [155]."
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"HERG1 contributes to poor prognosis in patients with ESCC by promoting ESCC cell proliferation, migration, and invasion via TXNDC5 through the PI3K and AKT signaling pathway."
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"Inhibition of HERG1 protein expression by siRNA reduced cell proliferation."
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"Kcnh2 depletion induces embryonic apoptosis rather than inhibiting proliferation."
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"To study whether inhibition of HERG channel protein expression would reduce SW2 cell proliferation, we first determined which members of the HERG channel family were expressed in SCLC cells."
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"Functionally, hERG1 may contribute to survival, proliferation, and metastasis of tumor cells."
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"The hERG promoter region contains multiple binding sites of oncogenes like Sp1, NF-κB and p53.97 Overexpression of hERG induces cell proliferation by accelerating cell cycle progression via altering the resting membrane potential of tumor cells."
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"11 It also has been shown that inhibition of hERG1 current activity can inhibit proliferation in leukemic cells by promoting cell cycle arrest."
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"This supports our suggestion that HERG would modulate MDA-MB-435S cells through interactions with membrane proteins, rather than through a modulation of the membrane potential.In addition to modulatin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the basis of the results discussed so far, blockade of hERG K + channels could downregulate cell proliferation [35] ."
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"Wang et al. showed that human ether a-go-go-related gene 1 (HERG1) promoted ESCC cell proliferation and metastasis through activating the PI3K/Akt signaling pathway (24)."
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"11, 34 Inhibition of Kcnh2 by si-RNA or inhibitor E4031 could remarkably attenuate cellular proliferation and migration due to inhibition the pathway of MAP kinase and c-fos."
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"For example, whereas inhibition of Kv11.1 function or expression reduces the proliferation of tumor cells in vitro and in vivo [19, 48–51], drugs developed to inhibit Kv11.1 cause cardiotoxicity [52]."
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"However, siRNA inhibition of HERG1 protein expression almost abolished HERG currents and strongly reduced SCLC cell proliferation."
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"Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-kappaB Pathway."
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"The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear."
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"HERG1 agonists cause irreversible inhibition of cell proliferation in human mammary gland adenocarcinoma derived cells."
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"To delineate the mechanism of action behind hERG1 promotion of osteosarcoma cell proliferation, we examined whether inhibition of hERG1 triggers apoptosis."
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"XREF_BIBR, XREF_BIBR In addition, genetic deletion of KCNE2 is associated with gastric neoplasia and increased nuclear cyclin D1 levels in mice, revealing genetic manipulation of cell proliferation mediated by a hERG beta-subunit."
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"We also demonstrate that hERG blockers reduced GPDC proliferation, and improved survival in patients who received one or more hERG blocking drugs but only if their tumors exhibited high hERG expression levels."
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"Based on hERG expression levels found in GSC derived xenografts, we wanted to determine whether hERG blockers could decrease proliferation rates in high hERG expressing GPDC lines more than low expressing hERG GPDC lines."
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"However, we do not know to which degree heteromeric HERG channels are formed and whether all or only HERG1 channel subunits support cell proliferation."
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"HERG1 displays a similar role in cancer lines, where hERG1 promotes proliferation and metastasis (51, 52)."
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"Meanwhile, it has been shown that KCNH1 and KCNH2 accelerate the proliferation of non-excitable cell-derived cancer cells, which has nothing to do with their ion conduction function [41,42]."
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"Inhibition of hERG1 with either E-4031 (10 muM and 20 muM) or knockdown with hERG1-siRNA reduced proliferation of osteosarcoma cells."
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"HERG1 has also been shown to enhance GC cell invasion and proliferation, induce cell cycle progression in vitro, and promote tumor genesis and growth in vivo."
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"Nevertheless, although HERG1 siRNA silencing caused a dramatic inhibition of cell proliferation, no major difference in cell proliferation was observed within the first 24 h."
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"11 , 34 Inhibition of Kcnh2 by si-RNA or inhibitor E4031 could remarkably attenuate cellular proliferation and migration due to inhibition the pathway of MAP kinase / c-fos ."
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"Given that overexpression of hERG1 promotes proliferation, migration and metastasis in ovarian cancer [49,50] , it was suggested that loss of expression of hERG1 by methylation could be a good prognos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"More recently, knockdown of HERG reduced proliferation, migration, and invasive ability of SKOV-3 cells, confirming HERG involvement in the pathogenesis of OC [XREF_BIBR, XREF_BIBR]."
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"In melanoma cells, HERG is also expressed, and inhibition of HERG with the non specific channel inhibitor imipramine decreased proliferation [22,27]."
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