IndraLab

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KCNH2 activates cell population proliferation. 45 / 46
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"HERG potassium channels enhance tumor invasiveness and breast cancer proliferation."
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"We also demonstrate that hERG blockers reduced GPDC proliferation, and improved survival in patients who received one or more hERG blocking drugs but only if their tumors exhibited high hERG expression levels."
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"HERG1 has also been shown to enhance GC cell invasion and proliferation, induce cell cycle progression in vitro, and promote tumor genesis and growth in vivo."
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"This suggests that ER-G1 stimulates cancer cell proliferation by enabling tumor expansion rather than directly stimulating cell growth and division.Based on tumor morphology, we hypothesized that ER-G[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The selective HERG channel blocker, E-4031, reduced proliferation of CEM, U937, and K562 cells, and this appears to be the first direct evidence of a functional role for the HERG current in cancer cells."
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"HERG blockers inhibit the proliferation at S and G2/M phase while Eag blocker impramine increases early apoptosis in ovarian cancer cells with no effect on cell cycle."
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"Yet, a significant number of Tn positive cells were detected in these livers, indicating that the expression of ER-G1, in the absence of NRas, is not toxic but does not induce cell growth or prolifera[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Blockade of the hERG potassium channel proteins by specific agents can inhibit the proliferation and metastasis of tumor cells and the corresponding [XREF_BIBR, XREF_BIBR], increasing the sensitivity of tumor cells to chemotherapeutic drugs."
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"Inhibition of HERG1 protein expression by siRNA reduced cell proliferation."
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"In contrast, siRNA induced inhibition of HERG1 protein expression decreased cell proliferation by about 50%."
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"Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-kappaB Pathway."
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"11 It also has been shown that inhibition of hERG1 current activity can inhibit proliferation in leukemic cells by promoting cell cycle arrest."
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"In control experiments, overexpression of HERG channels in HEK-293 cells dramatically increased the proliferation and migration of the cells and blocking HERG in these cells attenuated both proliferation and migration."
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"To test if ER-G1 promotes proliferation in vitro, we generated a series of stable cell lines expressing GFP, Golgi-G1, or ER-G1 in HCC derived HepG2 cells."
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"HERG1 agonists cause irreversible inhibition of cell proliferation in human mammary gland adenocarcinoma derived cells."
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"Our findings suggest that altered ERG1 expression may contribute to disease related smooth muscle proliferation and implicates these ion channels as potential targets as inhibitors of tumor driven neovascularization."
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"To study whether inhibition of HERG channel protein expression would reduce SW2 cell proliferation, we first determined which members of the HERG channel family were expressed in SCLC cells."
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"In the human neuroblastoma cell line SH-SY5Y [XREF_BIBR] and melanoma cells [XREF_BIBR], not only pharmacological ERG channel blockage but also inhibition of HERG channel protein expression effectively reduces cell proliferation."
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"Selective hERG channel blockade by E-4031 reduced proliferation in cancerous cell lines."
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"Based on hERG expression levels found in GSC derived xenografts, we wanted to determine whether hERG blockers could decrease proliferation rates in high hERG expressing GPDC lines more than low expressing hERG GPDC lines."
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"The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear."
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"Pharmacological inhibition of HERG channels reduces proliferation and impairs invasiveness in a variety of cancer cell types."
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"The knockdown of hERG reversed proliferation in a time dependent manner, as the rate of viable cells gradually downgraded to 58.3% +/- 6.4% 72 hours after the administration of nano-siRNA complexes (XREF_FIG)."
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"In addition, the CCK-8 assay, apoptosis and cell cycle analysis were performed and showed that blockage of HERG K + channels decreased the proliferation of MDS cells but rarely had effects on cell apoptosis and cell cycle distribution."
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"Functionally, hERG1 may contribute to survival, proliferation, and metastasis of tumor cells."
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"Interestingly, in primary cultures from leukaemia blasts, and in many cell lines, hERG1 inhibition tends to block cell proliferation (reviewed in Arcangeli, 2005; Arcangeli and Becchetti, 2005)."
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"Nevertheless, although HERG1 siRNA silencing caused a dramatic inhibition of cell proliferation, no major difference in cell proliferation was observed within the first 24 h."
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"Inhibition of HERG1 K + channel protein expression decreases cell proliferation of human small cell lung cancer cells."
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"This supports our suggestion that HERG would modulate MDA-MB-435S cells through interactions with membrane proteins, rather than through a modulation of the membrane potential.In addition to modulatin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"HERG1 contributes to poor prognosis in patients with ESCC by promoting ESCC cell proliferation, migration, and invasion via TXNDC5 through the PI3K and AKT signaling pathway."
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"HERG1 is over-expressed in various cancer cells and found to promote cell proliferation [XREF_BIBR - XREF_BIBR]."
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"The proliferation of SK-OV-3 cells is significantly inhibited by both Eag and HERG blockers."
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"However, we do not know to which degree heteromeric HERG channels are formed and whether all or only HERG1 channel subunits support cell proliferation."
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"Moreover, E-4031, a specific HERG channel blocker, reduced proliferation of uterine cancer cells."
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"To delineate the mechanism of action behind hERG1 promotion of osteosarcoma cell proliferation, we examined whether inhibition of hERG1 triggers apoptosis."
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"11, 34 Inhibition of Kcnh2 by si-RNA or inhibitor E4031 could remarkably attenuate cellular proliferation and migration due to inhibition the pathway of MAP kinase and c-fos."
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"Indeed, the knockdown of HERG1 inhibits cell proliferation, while its pharmacological inhibition by E4031 fails to affect cell proliferation."
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"Activation of hERG1 after 48 h of PD 118057 treatment (5 muM and 10 muM) increased proliferation of osteosarcoma cells."
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"However, siRNA inhibition of HERG1 protein expression almost abolished HERG currents and strongly reduced SCLC cell proliferation."
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"More recently, knockdown of HERG reduced proliferation, migration, and invasive ability of SKOV-3 cells, confirming HERG involvement in the pathogenesis of OC [XREF_BIBR, XREF_BIBR]."
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"In melanoma cells, HERG is also expressed, and inhibition of HERG with the non specific channel inhibitor imipramine decreased proliferation [22,27]."
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"Inhibition of hERG1 with either E-4031 (10 muM and 20 muM) or knockdown with hERG1-siRNA reduced proliferation of osteosarcoma cells."
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"XREF_BIBR, XREF_BIBR In addition, genetic deletion of KCNE2 is associated with gastric neoplasia and increased nuclear cyclin D1 levels in mice, revealing genetic manipulation of cell proliferation mediated by a hERG beta-subunit."
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"Thus, B-RAF-sensitive hERG K + channel up-regulation possibly contributes to cell proliferation and apoptosis of tumor cells."
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"11 , 34 Inhibition of Kcnh2 by si-RNA or inhibitor E4031 could remarkably attenuate cellular proliferation and migration due to inhibition the pathway of MAP kinase / c-fos ."
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