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USP2 inhibits PPARGC1B. 2 / 2

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"Indeed, the overexpression of the Usp2 gene decreased the quantity of K48-linked polyubiquitin chains on PGC1α, suggesting that USP2 is a direct stabilizing enzyme for PGC1α through deubiquitination."

39596006

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"Since USP2 stabilizes PGC1α by deubiquitination, USP2 might eliminate mitochondrial ROS by activating the PGC1α–UCP2 axis."

39596006

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IndraLab

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USP2 inhibits PPARGC1B. 2 / 2

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