IndraLab

Statements

Rottlerin activates KCNH2. 7 / 8
1 | 6
reach
"Mallotoxin, an alkaloid isolated from the tree Mallotus phillippinensis, increases hERG1 current amplitude by causing a hyperpolarizing shift in the voltage dependence of channel activation, with a maximum shift of -24 mV at 10 muM and an EC 50 of 0.5 muM [XREF_BIBR]."
24721650
reach
"As expected, mallotoxin activated hERG current by 87% at 3muM, and NS1643 activated hERG current by 55% at 3muM."
18493243
reach
"In contrast to KB130015, mallotoxin slows down hERG1 deactivation, suggesting a different mode of action."
20097192
reach
"Similar to KB130015, mallotoxin (MTx) activates the hERG1 channel by shifting its voltage dependence to the left and by accelerating activation."
20097192
dgi
No evidence text available
reach
"Mallotoxin, which activated hERG current by 87% at 3muM in hERG transfected HEK293 cells, significantly shortened the QT interval, JT interval and APD and increased Tp-Te and rTp-Te and coronary flow at 0.1 muM."
18493243
reach
"In this study, we showed that both mallotoxin and NS1643 activated hERG current by 87% and 55% at 3muM, respectively."
18493243