IndraLab

Statements

Isoflurane activates KCNK2. 16 / 18
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"Chloroform, diethyl ether, halothane and isoflurane activate TREK-1, whereas only halothane and isoflurane activate TASK."
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"Isoflurane also potentiates serotonin response via 5-HT 3 receptors, activates KCNK 2 (TREK-1) background K + channels (Liu et al. 2004; Lopes et al. 1998 ; Zhou et al. Isoflurane induced activation of TREK-1 channels resulting in the reduction of neuronal excitability."
34061250
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"These results suggest that TREK-1 activation by isoflurane protects the heart against excessive QT interval prolongation."
31511966
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"These results indicate that isoflurane administration may promote TREK-1 activity and apoptosis in astrocytes, and inhibit BDNF expression."
28944872
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"Notably, TREK-1 is activated by clinical concentrations of isoflurane, and is involved in the effects of isoflurane preconditioning."
28944872
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"These results suggest that TREK-1 activation by isoflurane protects the heart against excessive QT interval prolongation."
31511966
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"They were wrong: instead, it seems that exaggerated isoflurane activation of the TREK potassium channel in some neuronal populations was what drove the lower MAC of isoflurane."
33909884
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"Chloroform, diethyl ether, halothane and isoflurane activate TREK-1, whereas only halothane and isoflurane activate TASK."
32106800
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"We reasoned that activation of TREK-1 by isoflurane would result in attenuated isoflurane-induced QT interval prolongation."
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"XREF_BIBR examined TASK and TREK-1, and found that TREK-1 was activated by chloroform, diethyl ether, halothane and isoflurane, while TASK was activated by halothane and isoflurane."
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"Isoflurane activates TREK1 two pore domain K2P potassium channels which are abundantly expressed in hippocampal neurons and are important K + leak channels that modulate the RMP to control excitability."
33854415
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"A, B Isoflurane induced activation of TREK-1 channels resulting in the reduction of neuronal excitability."
34061250
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"Chloroform, diethyl ether, halothane and isoflurane activated TREK-1, whereas only halothane and isoflurane activated TASK."
10321245
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"We reasoned that activation of TREK-1 by isoflurane would result in attenuated isoflurane-induced QT interval prolongation."
31511966
dgi
No evidence text available
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"If the chloroform seems to be selective for TREK-1 channels with an EC 50 (0.2–1.6 mM), halothane and isoflurane activate both TREK-1 and TASK channels."
31031627