IndraLab

Statements

Isoflurane activates KCNK2. 16 / 18
| 11 5
sparser
"If the chloroform seems to be selective for TREK-1 channels with an EC 50 (0.2–1.6 mM), halothane and isoflurane activate both TREK-1 and TASK channels."
31031627
reach
"These results indicate that isoflurane administration may promote TREK-1 activity and apoptosis in astrocytes, and inhibit BDNF expression."
28944872
reach
"Chloroform, diethyl ether, halothane and isoflurane activate TREK-1, whereas only halothane and isoflurane activate TASK."
32106800
reach
"We reasoned that activation of TREK-1 by isoflurane would result in attenuated isoflurane-induced QT interval prolongation."
31511966
reach
"These results suggest that TREK-1 activation by isoflurane protects the heart against excessive QT interval prolongation."
31511966
reach
"Notably, TREK-1 is activated by clinical concentrations of isoflurane, and is involved in the effects of isoflurane preconditioning."
28944872
reach
"They were wrong: instead, it seems that exaggerated isoflurane activation of the TREK potassium channel in some neuronal populations was what drove the lower MAC of isoflurane."
33909884
sparser
"Chloroform, diethyl ether, halothane and isoflurane activate TREK-1, whereas only halothane and isoflurane activate TASK."
32106800
sparser
"Trek-1 is activated by isoflurane and other volatile anesthetics at clinically relevant doses, a response that is dependent on the intracellular C-terminus of the channel [ xref ]; channel activation involves lipid binding to this portion of the channel following administration of anesthetic [ xref ]."
33588730
reach
"XREF_BIBR examined TASK and TREK-1, and found that TREK-1 was activated by chloroform, diethyl ether, halothane and isoflurane, while TASK was activated by halothane and isoflurane."
20735416
sparser
"We reasoned that activation of TREK-1 by isoflurane would result in attenuated isoflurane-induced QT interval prolongation."
31511966
sparser
"These results suggest that TREK-1 activation by isoflurane protects the heart against excessive QT interval prolongation."
31511966
reach
"Trek-1 is activated by isoflurane and other volatile anesthetics at clinically relevant doses, a response that is dependent on the intracellular C-terminus of the channel [37]; channel activation involves lipid binding to this portion of the channel following administration of anesthetic [38]."
33588730
reach
"Isoflurane activates TREK1 two pore domain K2P potassium channels which are abundantly expressed in hippocampal neurons and are important K + leak channels that modulate the RMP to control excitability."
33854415
reach
"Chloroform, diethyl ether, halothane and isoflurane activated TREK-1, whereas only halothane and isoflurane activated TASK."
10321245
reach
"Halothane and Isoflurane were found to activate KCNK2 in HEK-293 cells [82]."
39420106