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EMMAA Bob with Bioagents

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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

UCHL1 decreases the amount of PHLPP1. 6 / 6

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"If UCH-L1 suppressed the transcription of PHLPP1, we would expect to see an increase in PHLPP1 mRNA levels upon UCH-L1 depletion."

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"In contrast, we observed a dramatic increase in the phosphatase PHLPP1 levels following depletion of UCH-L1 (XREF_FIG and XREF_SUPPLEMENTARY)."

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"UCH-L1 leads to reduced levels of PHLPP1, and boosts Akt signaling."

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"These data suggest that UCH-L1 leads to reduced PHLPP1 levels in a non-proteasome-dependent manner."

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"UCH-L1 activity leads to reduced levels of the phosphatase PHLPP1."

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"For instance, UCH-L1 decreases PHLPP expression leading to prolonged Akt signaling in lymphomagenesis 19."

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