IndraLab

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"If UCH-L1 suppressed the transcription of PHLPP1, we would expect to see an increase in PHLPP1 mRNA levels upon UCH-L1 depletion."

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"In contrast, we observed a dramatic increase in the phosphatase PHLPP1 levels following depletion of UCH-L1 (XREF_FIG and XREF_SUPPLEMENTARY)."

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"UCH-L1 leads to reduced levels of PHLPP1, and boosts Akt signaling."

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"These data suggest that UCH-L1 leads to reduced PHLPP1 levels in a non-proteasome-dependent manner."

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"UCH-L1 activity leads to reduced levels of the phosphatase PHLPP1."

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"For instance, UCH-L1 decreases PHLPP expression leading to prolonged Akt signaling in lymphomagenesis 19."

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