IndraLab

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BAP1 inhibits γ-globin. 2 / 2
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"To delve more deeply into the underlying mechanism by which BAP1 mediates repression of γ-globin synthesis, it would be of great significance to determine the identity of additional BAP1 target proteins in erythroid cells in future studies."
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"We also showed that a novel DRED repressor subunit, deubiquitinase BAP1, regulates site-specific NCoR1 recruitment within the β-globin locus and that BAP1 reduction leads to enormously increased γ-globin mRNA and protein induction (Fig. 5D)."
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