IndraLab

Statements

Lipopolysaccharide inhibits TRAF3. 7 / 7
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"The TLR4 ligand LPS stimulates TRAF3 degradation in both the Raw264.7 macrophage cell line and the CNS-resident macrophages, which likely serves as a mechanism to override the inhibitory function of TRAF3 XREF_BIBR, XREF_BIBR."
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"Like TRAF3, TRAF2 negatively regulate induction of proinflammatory cytokines by the TLR ligands LPS and polyIC as well as by the cytokine IL-1β, and the myeloid cell-conditional TRAF2 knockout (TRAF2-MKO) mice are hypersensitive to colitis induction in the DSS model (126)."
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"It has been shown that the TLR4 ligand LPS stimulates TRAF3 degradation in a macrophage cell line (Raw264.7) and primary microglia, although this signaling event is weak in bone marrow derived macrophages."
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"Congruently, TRAF6 ablation inhibited LPS induced TRAF3 degradation (XREF_FIG)."
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"The LPS stimulated Traf3 degradation was blocked in the Peli1 deficient microglia (XREF_FIG), which could be rescued by reconstitution with exogenous Peli1 (XREF_SUPPLEMENTARY)."
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"Treatment of cells with the proteasome inhibitor MG132 inhibited the LPS stimulated degradation of TRAF3 in wild-type and Usp25 -/- BMDMs (XREF_FIG)."
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"We found that LPS stimulated rapid degradation of Traf3 in wild-type microglia (XREF_FIG), although such a signaling event was much less prominent in BM derived macrophages (data not shown)."
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