IndraLab

Statements

USP25 activates FOXM1. 12 / 12
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"The expression of USP21 WT increased FOXM1 stability, and its half-life was approximately 12.4 h."
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"USP21 Promotes the Progression of Nasopharyngeal Carcinoma by Regulating FOXM1."
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"USP21 overexpression significantly enhanced FOXM1 dependent transcriptional activity compared with control (XREF_FIG)."
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"This is consistent with our previous data demonstrating that FOXM1 abundance is positively enhanced by USP21 overexpression."
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"Because FOXM1 is upregulated by USP21, we asked whether a curated list of 114 FOXM1 target genes is correlated with USP21 amplification using gene set enrichment analysis (GSEA)."
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"USP21 stabilizes FOXM1, and suppressing USP21 reduces FOXM1 abundance, which subsequently downregulates the FOXM1 transcriptional network."
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"These findings proved that USP21 promoted tumor growth and cancer cell stemness in nasopharyngeal carcinoma by regulating FOXM1."
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"USP21 increases the stability of FOXM1, and USP21 binds and deubiquitinates FOXM1 in vivo and in vitro, indicating a direct enzyme-substrate relationship."
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"Retracted: USP21 Promotes the Progression of Nasopharyngeal Carcinoma by Regulating FOXM1."
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"In our study, the results showed that USP21 positively regulated FOXM1 expression, and overexpression of FOXM1 could reverse the cell proliferation ability, cell migration and invasion ability, and cell stemness profiles, suggesting that USP21 promoted nasopharyngeal carcinoma progression through regulating FOXM1 expression.In conclusion, this study demonstrated the mRNA and protein expression of USP21 was higher in nasopharyngeal carcinoma tissues or cell lines than normal tissue or normal nasopharyngeal epithelial cells, respectively."
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"Correspondingly, ectopic expression of USP21 significantly increased FOXM1 abundance in 293T cells (XREF_FIG)."
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"USP21 activated the Hippo pathway by mediating FOXM1."
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