IndraLab

Statements

USP25 activates FOXM1. 10 / 10
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"The expression of USP21 WT increased FOXM1 stability, and its half-life was approximately 12.4 h."
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"This is consistent with our previous data demonstrating that FOXM1 abundance is positively enhanced by USP21 overexpression."
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"These findings proved that USP21 promoted tumor growth and cancer cell stemness in nasopharyngeal carcinoma by regulating FOXM1."
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"USP21 increases the stability of FOXM1, and USP21 binds and deubiquitinates FOXM1 in vivo and in vitro, indicating a direct enzyme-substrate relationship."
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"USP21 stabilizes FOXM1, and suppressing USP21 reduces FOXM1 abundance, which subsequently downregulates the FOXM1 transcriptional network."
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"Correspondingly, ectopic expression of USP21 significantly increased FOXM1 abundance in 293T cells (XREF_FIG)."
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"USP21 activated the Hippo pathway by mediating FOXM1."
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"USP21 Promotes the Progression of Nasopharyngeal Carcinoma by Regulating FOXM1."
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"USP21 overexpression significantly enhanced FOXM1 dependent transcriptional activity compared with control (XREF_FIG)."
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"Because FOXM1 is upregulated by USP21, we asked whether a curated list of 114 FOXM1 target genes is correlated with USP21 amplification using gene set enrichment analysis (GSEA)."
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