IndraLab

Statements

P5091 activates cell growth. 5 / 5
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"The small-molecule inhibitor P5091 targeting USP7 effectively suppresses the Warburg effect and cell growth in PDAC."
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"Prior studies have also shown that the USP7 inhibitors P5091 and P22077 inhibit NB cell growth through destabilization of N-Myc, independent of TP53 status, and identified direct interactions between USP7 and N-Myc [13]."
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"In doing that, USP7 inhibitor P5091 activates an apoptotic and cell growth arrest response which occurs by passing TP53 genetic loss."
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"Treatment of primary CLL samples and cell lines with P5091 induces cell growth arrest and apoptosis, through the restoration of PTEN nuclear pool, both in TP53-wild type and -null environment."
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"Intriguingly, the USP7 inhibitor (P5091) significantly inhibited myeloma cells’ cell growth and overcame NEK2-induced and -acquired BTZ resistance (Franqui-Machin et al., 2018)."
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