IndraLab

Statements

PTEN binds BAP1. 16 / 16
7 | 1 8
sparser
"In analyses adjusted only for cohort, mutations in BAP1 (median: 8 vs 5.2 cm; p = 0.001) and PTEN (median: 8 vs 5.9 cm; p = 0.026) were significantly associated with larger median tumor diameter."
28753773
sparser
"BAP1 can physically bind to and deubiquitinate PTEN, which inhibits the ubiquitination-mediated degradation of PTEN and thus stabilizes PTEN protein."
33155366
sparser
"These findings demonstrate that BAP1 is an important deubiquitinase of PTEN for its stability and the BAP1-PTEN signaling axis plays a crucial role in tumor suppression."
33155366
sparser
"Mechanistically, BAP1 interacts with PTEN and stabilizes PTEN through deubiquitination, and further negatively regulates HCC cell EMT by inactivating the AKT/GSK-3β/Snail pathway."
40607251
sparser
"In our cohort, BAP1 and PTEN are significantly associated with a higher tumor grade and DNM2 is significantly associated with a lower tumor grade."
39123175
sparser
"MiR-200c-3p in M2 macrophage exosomes can influence the PI3K/AKT signaling pathway via obstructing the interaction between BAP1 gene and PTEN gene in hepatocytes, which could strengthen the resistance to sorafenib ( xref )."
41567219
sparser
"In PUCH- ccRCC cohort, BAP1 and PTEN are significantly associated with a higher tumor grade (G3&G4, P  = 0.004; P  = 0.030)."
39123175
sparser
"Though BAP1 and PTEN is not significantly associated with a higher tumor grade ( P  > 0.05), the percentage of G3&G4 is higher in both BAP1 and PTEN mutation groups."
39123175
biogrid
No evidence text available
15717329
biogrid
No evidence text available
33155366
biogrid
No evidence text available
33155366
biogrid
No evidence text available
33155366
biogrid
No evidence text available
33155366
reach
"BAP1 can physically bind to and deubiquitinate PTEN, which inhibits the ubiquitination mediated degradation of PTEN and thus stabilizes PTEN protein."
33155366
biogrid
No evidence text available
34094668
biogrid
No evidence text available
34094668