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3',5'-cyclic AMP inhibits JUN. 13 / 13
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"HDAC4 mediates cAMP dependent repression of c-Jun in cultured Schwann cells."
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"During B cell activation, cAMP negatively regulates raf-1 and erk-2, but not Jun kinase activation in response to BCR ligation, while activation of both erk-2 and Jun kinase through the PKA-insensitiv[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, other studies suggest that cAMP mediated signals can repress induction of c-jun through this element (de Groot et al. 1991; Mechta et al. 1989)."
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"Finally, these authors demonstrate that the capacity of cAMP to downregulate c-Jun in Schwann cells disappears when the deacetylase activity is inhibited with triscostatin A."
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"Intriguingly, cAMP down-regulates c-Jun, a basic leucine zipper domain transcription factor expressed by immature Schwann cells that negatively regulates the expression of the myelin master gene Krox20."
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"In summary, we propose a model in which class IIa HDACs are pivotal components of an intracellular cAMP sensor mechanism that blocks c-Jun, allowing the activation of the myelin gene expression program and differentiation of Schwann cells."
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"In primary hepatocyte cultures, supplemental cAMP inhibited JNK and ERK activity, total AP-1 and c-Jun transcriptional activities, and DNA synthesis."
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"Neither cyclic AMP response element binding protein nor c-fos antisense oligonucleotide injection reduced c-Jun immunostaining in the striatum."
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"Interestingly, c-Jun up-regulation and the transition to the activated phenotype can be blocked by cAMP."
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"Finally, c-Jun down-regulation by cAMP was reversed by incubation with 2 microM TSA, a deacetylase inhibitor that efficiently inhibits class I HDACs (including HDAC3) and class IIb HDACs but not class IIa HDACs."
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"Loss of HDAC4 function prevented not only cAMP induced c-Jun down-regulation but also induction of Krox20 (immunofluorescence intensity = 74.89 +/- 1.89 a.u. for Lv control infected cells and 30.36 +/- 0.78 a.u. for Lv shHDAc4 infected Schwann cells; XREF_FIG) and Periaxin (81.29 +/- 2.28 in control vs. 42.63 +/- 1.52 in Lv shHDAC4 infected cells; XREF_FIG)."
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"In T cells, however, cAMP accumulation inhibits the activity of Jun kinase but not MAPK (Hsueh and Lai, 1995), suggesting that differential targets of PKA exist in distinct cell types."
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"Transcription of c-Jun is induced by ERK5, and like ERK5, c-Jun induction is also blocked by cAMP."
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