IndraLab

Statements

COPS5 activates cellular senescence. 5 / 5
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"Depletion of CSN5 suppressed cell proliferation, and induced premature senescence characterized by upregulation of senescence-associated-beta-galactosidase activity and increased expression of CDK inhibitors."
23127558
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"Further studies revealed that depletion of Jab1 inhibited cell proliferation, and induced premature senescence characterized by upregulation of senescence associated- beta-galactosidase activity and increased expression of CDK inhibitors."
29535627
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"CSN5 and Jab1 elimination inhibited progression of the cell cycle at multiple points, seemed to initiate p53 independent senescence and increased the ploidy of cells."
20974137
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"It will be promising to explore small molecules which inhibit interaction between Jab1 and CDK2 but do n't affect the deneddylase activity of Jab1, which may induce senescence without affecting global proliferation and the cell cycle, resulting in the development of anti-cancer drugs with minimum side effects."
29535627
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"Depletion of CSN5 induces senescence in p53-null fibroblasts XREF_BIBR, but knockout of the CSN5 gene upregulates p53 expression XREF_BIBR, indicating that CSN5 occurs upstream of both p53 dependent and -independent senescence pathways (XREF_FIG) and that interaction between CSN5 and CDK2 may take part in the p53 independent pathway."
23316279