IndraLab

Statements

COPS5 activates cellular senescence. 5 / 5
| 5
reach
"It will be promising to explore small molecules which inhibit interaction between Jab1 and CDK2 but do n't affect the deneddylase activity of Jab1, which may induce senescence without affecting global proliferation and the cell cycle, resulting in the development of anti-cancer drugs with minimum side effects."
29535627
reach
"Depletion of CSN5 induces senescence in p53-null fibroblasts XREF_BIBR, but knockout of the CSN5 gene upregulates p53 expression XREF_BIBR, indicating that CSN5 occurs upstream of both p53 dependent and -independent senescence pathways (XREF_FIG) and that interaction between CSN5 and CDK2 may take part in the p53 independent pathway."
23316279
reach
"Senescent OPCs and JAB1-mediated senescence in oligodendrocytes illuminate potential avenues for therapeutic interventions aimed at mitigating neurodegenerative processes."
38030088
reach
"Whatever the mechanism, it is feasible that a CSN5-associated function is required for the Ras-mediated transformation of cells to prevent premature senescence and, therefore, CSN5 is a novel target f[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23127558
reach
"Further studies revealed that depletion of Jab1 inhibited cell proliferation, and induced premature senescence characterized by upregulation of senescence associated- beta-galactosidase activity and increased expression of CDK inhibitors."
29535627