IndraLab

Statements

OTUB2 activates chloroethene. 6 / 6
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"Since OTUB2 modulates YAP activity and VC progression, we next sought to investigate the potential regulatory mechanisms between OTUB2 and YAP."
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"The knockdown or inhibition of PFKFB3 alleviated the procalcific effects of OTUB2.Conclusions: Our findings indicate that OTUB2 promotes VC at least partially by activating the YAP-PFKFB3 signaling pathway."
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"In this study, we revealed that OTUB2 promoted VSMC osteogenic differentiation and aggravated VC both in vivo and in vitro."
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"OTUB2 accelerates the development of VC."
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"Given that OTUB2 is upregulated during VC development, we next sought to evaluate whether OTUB2 overexpression might accelerate VC."
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"Knockdown or inhibition of YAP partially suppresses VC promoted by OTUB2 overexpression."
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