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"USP15 is a direct target of miR-202-5p Because we found that USP15 downregulation led to decreased apoptosis in CML cells by lowering the level of Caspase-6 protein , we sought to know whether the expression of USP15 is suppressed in CML cells by a microRNA that targets 3 ' - untranslated region ( 3 ' - UTR ) of USP15 mRNA ."