IndraLab

Statements


| 7

reach
"We have recently shown that RA attenuates the response of NGFI-B and c-Fos to NGF, but does not alter NGF induction of NGFI-A [12]."

reach
"RA attenuates the response of NGFI-B and c-Fos to NGF, but does not alter NGF induction of NGFI-A."

reach
"That repression of c-fos by RA might contribute to anti-AP-1 activity was suggested by experiments with an antisense c-fos expression vector, which demonstrated that c-fos induction was required for serum stimulated AP-1 activity."

reach
"Moreover, cotreatment of 13-cis RA and 1, 25-VD3 reduced the nuclear levels of Rel A (p65 NF-kappaB), c-fos and phosphorylated- c-Jun proteins (AP-1 protein) in human PDAC cells (XREF_FIG)."

reach
"Our results already demonstrated that co-treatment of 13-cis RA and 1, 25-VD3 significantly inhibited TNF-alpha-mediated activation of JNK pathway and downstream AP-1 proteins (c-fos and p-c-jun proteins) expression human PDAC cells (XREF_FIG)."

reach
"RA blocked c-fos induction by inhibiting transcription."

reach
"C-fos is downregulated by RA in parallel to the inhibition of the cell division rate."