IndraLab

Statements

Calcium(2+) activates KCNH2. 6 / 6
| 6
reach
"Several preclinical studies suggest an important role for sodium, potassium (Ca activated, outward rectifying, and hERG) and chloride ion-channels as well as Na-K-Cl cotransporter on GBM cell migration and parenchymal invasion, possibly through effects on cellular volume and shape."
27384764
reach
"Further research has revealed that simultaneous block of other ion channels, especially the late sodium and the L-type calcium channel, can attenuate the proarrhythmic effects of pure hERG and IKr block despite the presence of QT prolongation."
33071822
reach
"We recently found that extracellular Ca 2+ can modulate the voltage dependence of HERG channel activation independently of inactivation (Johnson et al., 1999)."
10545354
reach
"Elevated extracellular K + (20 mM) decreases the shift in the HERG channel isochronal current-voltage curve caused by Ca 2+."
10102937
reach
"These changes reflect altered hERG1 gating because no rapid currents were induced in uninjected oocytes treated with these concentrations of Ca 2+ or Cd 2+ (XREF_FIG)."
20660661
reach
"Although we can not definitively rule out the possibility that Ca 2+ causes an allosteric change in HERG channels that mimics a specific association near the activation voltage sensor, our data are consistent with a simple Ca 2+ -induced change in membrane potential sensed specifically by the activation process."
10102937